Goodman Craig, Knoll Gabriella, Isakov Victoria, Silver Henry
Brain Behavior Laboratory, Sha'ar Menashe Mental Health Center, Hefer, Israel.
Int Clin Psychopharmacol. 2005 Mar;20(2):93-6. doi: 10.1097/00004850-200503000-00005.
A lack of insight into illness and negative attitudes towards medication are common among individuals with schizophrenia and impact clinical outcomes. This study aimed to examine the relationships between attitudes towards medication and cognitive function in schizophrenia patients. Thirty-five male forensic inpatients who were suffering from chronic schizophrenia participated in the study. A drug attitude inventory was used to evaluate the attitudes of the patients towards medication. Neuropsychological function was assessed with a comprehensive battery of tests. Patients with positive attitudes towards medication performed significantly better than those with negative attitudes on tests of verbal working memory (digit span forwards and backwards), inhibition and set shifting (Penn Inhibition test), delayed object memory and overall mental status (Mini Mental State Examination). There were no differences in age, education, hospitalizations or clinical symptoms between the groups. Our findings support an association between negative attitudes towards medication and poor cognitive performance, particularly of working memory.
对疾病缺乏洞察力以及对药物治疗持消极态度在精神分裂症患者中很常见，且会影响临床治疗效果。本研究旨在探讨精神分裂症患者对药物治疗的态度与认知功能之间的关系。35名患有慢性精神分裂症的男性法医住院患者参与了该研究。使用药物态度量表来评估患者对药物治疗的态度。通过一系列综合测试评估神经心理功能。在言语工作记忆测试（顺背和倒背数字广度）、抑制和定势转换测试（宾夕法尼亚抑制测试）、延迟物体记忆和整体精神状态测试（简易精神状态检查表）中，对药物治疗持积极态度的患者表现明显优于持消极态度的患者。两组在年龄、教育程度、住院次数或临床症状方面没有差异。我们的研究结果支持对药物治疗的消极态度与较差的认知表现之间存在关联，尤其是工作记忆方面。
