Lee Sang Won, Kim You Chan, Kim Dong Kun, Yoon Tae Young, Park Hyang Joon, Cinn Yong Woo
Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea.
J Dermatol. 2004 Nov;31(11):904-9. doi: 10.1111/j.1346-8138.2004.tb00624.x.
Melanonychia is characterized by tan, brown, or black pigmentation within the nail plate. Fungal melanonychia is rare and may simulate longitudinal melanonychia caused by melanocytic lesions. We report six cases of fungal melanonychia which were confirmed histopathologically or mycologically. On culture, Candida and/or Aspergillus species were isolated in four patients. The nail pigmentation improved after treatment with antifungal agents in all cases, but one patient experienced a new lesion on another nail after cessation of treatment. Fungal infection should be considered as a cause of melanonychia, and fungal melanonychia should be differentiated from the melanonychia caused by melanocytic lesions, particularly by subungual melanoma.
甲下黑素沉着表现为甲板内棕褐色或黑色色素沉着。真菌性甲下黑素沉着较为罕见，可能类似黑素细胞病变引起的纵向甲下黑素沉着。我们报告6例经组织病理学或真菌学确诊的真菌性甲下黑素沉着病例。在培养时，4例患者分离出念珠菌和/或曲霉菌种。所有病例经抗真菌药物治疗后甲色素沉着均有改善，但1例患者在停药后另一指甲出现新病变。真菌感染应被视为甲下黑素沉着的一个病因，真菌性甲下黑素沉着应与黑素细胞病变尤其是甲下黑色素瘤引起的甲下黑素沉着相鉴别。
