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[产前保健的使用与小于胎龄儿出生风险。罗兹省一项病例对照研究的初步结果]

[Use of prenatal health care and risk of infants born small-for-gestational-age. Preliminary results of a case-control study in the Lódź voivodeship].

作者信息

Cieśla Bogumiła, Hanke Wojciech, Grodzicka Alicja, Gulczyńska Ewa, Pawłowska Barbara, Wasilewska-Wilk Ewa

机构信息

Wojewódzkie Centrum Zdrowia Publicznego w Lodzi.

出版信息

Przegl Epidemiol. 2004;58(3):537-46.

Abstract

It is well documented that small-for-gestational age (SGA) infants are at an increased risk of perinatal mortality and morbidity. In order to identify the major modifiable risk factors of SGA birth, a case-control study was launched in the area of Lódź voivodeship, Poland. The project was focused on the evaluation of the role of perinatal health services and avoidance of exposure to tobacco smoke in the prevention of SGA births. The study population consisted of mothers of 153 SGA infants (cases) and 93 mothers of control infants. SGA infants were identified as infants with body weight below 10th percentile for gestational age, using Ballarda scale. The controls were non-SGA infants delivered after 37 week of gestation. The infants from both groups were delivered in 26 maternity wards in the Lódź voivodeship within the period of June 1-November 1, 2003. One month after delivery, each mother of SGA and control infants was visited by an interviewer who collected information about her profile of use of perinatal health care and on active and passive exposure to tobacco smoke in pregnancy. Odds ratios and 95% confidence units (CU) were calculated using EpiInfo software developed by CDC, Atlanta, Georgia, US. Late booking for perinatal care (after 12 week of gestation) and less than 5 visits during pregnancy was found to be related to an increased risk of SGA, however, the OR values included unity. About 1/3 of mothers of SGA infants and "of the controls were served mainly by the private health sector. The use of private care was related to a lower risk of SGA: OR= 0.55 95% CI (0.31-0.96). This protective pattern was observed in the population of women aged 19-25 living in rural areas years and with only primary education. The preconception visits to obstetricians and contacts with health educators during pregnancy were also found to have some protective effect, however, the ORs were not statistically significant. The adverse effect of smoking during pregnancy was clearly confirmed in the study population, OR= 2.69 95%CI (1.37-5.33), while the role of passive smoking was difficult to assess due to the small number of nonsmoking women exposed to ETS. There are some indications that the poor use of perinatal health services may account for the elevated risk of SGA births in the Lódź voivodeship. The use of the private health sector is growing and seems to be related to a lower risk of SGA births. More effective tools to prevent maternal smoking have to be developed and implemented in routine perinatal care.

摘要

有充分文献记载,小于胎龄(SGA)婴儿围产期死亡率和发病率较高。为了确定SGA出生的主要可改变风险因素,在波兰罗兹省开展了一项病例对照研究。该项目重点评估围产期保健服务的作用以及避免接触烟草烟雾在预防SGA出生方面的作用。研究人群包括153名SGA婴儿的母亲(病例组)和93名对照婴儿的母亲。使用巴拉尔达量表将SGA婴儿确定为体重低于胎龄第10百分位数的婴儿。对照组为妊娠37周后出生的非SGA婴儿。两组婴儿于2003年6月1日至11月1日期间在罗兹省的26个产科病房出生。分娩后一个月,SGA婴儿和对照婴儿的每位母亲都接受了访员的访问,访员收集了有关她使用围产期保健情况以及孕期主动和被动接触烟草烟雾的信息。使用美国佐治亚州亚特兰大疾病控制与预防中心开发的EpiInfo软件计算比值比和95%置信区间(CI)。发现围产期保健预约晚(妊娠12周后)以及孕期就诊次数少于5次与SGA风险增加有关,然而,比值比数值包含1。约1/3的SGA婴儿母亲和对照婴儿母亲主要由私立医疗部门提供服务。使用私立医疗与较低的SGA风险有关:比值比=0.55,95%置信区间(0.31 - 0.96)。在年龄为(此处原文可能有误,推测为19 - 25岁)、居住在农村地区且只有小学教育程度的女性人群中观察到了这种保护模式。孕前看产科医生以及孕期与健康教育工作者接触也被发现有一定保护作用,然而,比值比无统计学意义。研究人群中明确证实了孕期吸烟的不良影响,比值比=2.69,95%置信区间(1.37 - 5.33),而由于接触二手烟的非吸烟女性数量较少,难以评估被动吸烟的作用。有一些迹象表明,围产期保健服务利用不足可能是罗兹省SGA出生风险升高的原因。私立医疗部门的使用在增加,似乎与较低的SGA出生风险有关。必须开发更有效的工具来预防孕妇吸烟,并在常规围产期保健中实施。

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