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一类钾通道阻滞剂-乙酰胆碱释放剂：治疗阿尔茨海默病的新潜力？综述

A group of potassium-channel blockers-acetylcholine releasers: new potentials for Alzheimer disease? A review.

作者信息

Lavretsky E P, Jarvik L F

机构信息

West Los Angeles VA Medical Center, California.

出版信息

J Clin Psychopharmacol. 1992 Apr;12(2):110-8.

PMID:1573033
Abstract

This review of the literature examines systematically the data currently available for potassium-channel blockers to reassess their clinical potential in Alzheimer disease. The conclusion is that potassium-channel blockers may have been dismissed prematurely for the treatment of Alzheimer disease, an impression supported by data indicating intimate relationships between potassium-channel blockade and cholinergic transmission.

摘要

这篇文献综述系统地研究了目前可获得的关于钾通道阻滞剂的数据，以重新评估它们在阿尔茨海默病中的临床潜力。结论是，钾通道阻滞剂在治疗阿尔茨海默病方面可能被过早摒弃，有数据表明钾通道阻滞与胆碱能传递之间存在密切关系，这一观点也支持了这一结论。

相似文献

1
A group of potassium-channel blockers-acetylcholine releasers: new potentials for Alzheimer disease? A review.一类钾通道阻滞剂-乙酰胆碱释放剂：治疗阿尔茨海默病的新潜力？综述
J Clin Psychopharmacol. 1992 Apr;12(2):110-8.
2
Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.阿尔茨海默病中的胆碱能标志物与乙酰胆碱释放的自动调节。
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[Cholinergic treatment strategies in Alzheimer's disease].
Nervenarzt. 1986 Oct;57(10):558-69.
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Manipulation of the cholinergic system.胆碱能系统的调控
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Multiple actions of THA on cholinergic neurotransmission in Alzheimer brains.他克林对阿尔茨海默病大脑胆碱能神经传递的多种作用。
Prog Clin Biol Res. 1989;317:1169-78.
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Optimism in the treatment of Alzheimer's disease.阿尔茨海默病治疗中的乐观态度。
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Cholinergic drugs, affective disorders and dementia: problems of clinical research.
Acta Psychiatr Scand Suppl. 1991;366:66-9. doi: 10.1111/j.1600-0447.1991.tb03112.x.
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Pharmacologic challenges in Alzheimer disease and normal controls: cognitive modeling in humans.
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Repositioning medication for cardiovascular and cerebrovascular disease to delay the onset and prevent progression of Alzheimer's disease.将心血管和脑血管疾病药物重新定位，以延缓阿尔茨海默病的发病和进展。
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Short-Term High-Fat Diet (HFD) Induced Anxiety-Like Behaviors and Cognitive Impairment Are Improved with Treatment by Glyburide.短期高脂饮食（HFD）诱导的焦虑样行为和认知障碍通过格列本脲治疗得到改善。
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Lack of effect of Z-butylidenephthalide on presynaptic N-type Ca²⁺ channels in isolated guinea-pig ileum.
Z-丁烯基苯酞对离体豚鼠回肠突触前N型钙离子通道无作用。
Naunyn Schmiedebergs Arch Pharmacol. 2016 Feb;389(2):159-66. doi: 10.1007/s00210-015-1183-5.
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Butylidenephthalide blocks potassium channels and enhances basal tension in isolated guinea-pig trachea.丁烯基苯酞可阻断豚鼠离体气管中的钾通道并增强基础张力。
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Neuropathobiology of senile dementia and mechanism of action of nootropic drugs.老年痴呆的神经病理生物学及促智药的作用机制
Drugs Aging. 1994 Apr;4(4):285-303. doi: 10.2165/00002512-199404040-00002.