通过β-内酰胺中间体合成β-氨基酸药效基团。
Synthesis of a beta-amino acid pharmacophore via a beta-lactam intermediate.
作者信息
Angelaud Rémy, Zhong Yong-Li, Maligres Peter, Lee Jaemoon, Askin David
机构信息
Merck Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.
出版信息
J Org Chem. 2005 Mar 4;70(5):1949-52. doi: 10.1021/jo048249c.
PMID:15730331
Abstract
A stereoselective synthesis of (R)-beta-amino acid 1 via a beta-lactam intermediate is discussed.
摘要
讨论了通过β-内酰胺中间体对(R)-β-氨基酸1进行立体选择性合成的方法。
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