Cermeño Julman R, Cermeño Julmery J, Hernández Isabel, Godoy Gerardo, Cermeño July J, Cabello Ismery, Orellán Yida, Blanco Ytalia, Penna Salvador
Departamento de Parasitología y Microbiología, Universidad de Oriente, Bolívar, Venezuela.
Trop Med Int Health. 2005 Mar;10(3):216-9. doi: 10.1111/j.1365-3156.2004.01376.x.
To determine the prevalence of histoplasmosis and paracoccidiomycosis in Upata, a city in Bolivar state, Venezuela.
Cutaneous tests on 397 volunteers, 204 with histoplasmine and 193 with paracoccidioidine. Epidemiological data were collected in a protocol sheet. Readings were performed at 24 and 48 h post-injection, by the same observer, and a positive reaction was defined as hardened papule of 5 mm or more.
Histoplasmine tests were positive in 19.6% and 34.0% at 24 and 48 h after antigens injection with a significant increase of reactivity (P=0.0019). Paracoccidiodine tests were positive in 11.3% and 19.7% at 24 and 48 h respectively and this difference was also significant (P=0.004). Risk factors which could explain these levels of reactivity could not be clearly identified. Cultures and animal inoculation from soil samples for fungus isolation were negative.
Paracoccidioidomycoses and histoplasmosis are endemic in Upata.
确定委内瑞拉玻利瓦尔州乌帕塔市组织胞浆菌病和副球孢子菌病的患病率。
对397名志愿者进行皮肤试验，其中204人用组织胞浆菌素，193人用副球孢子菌素。通过一份方案表收集流行病学数据。由同一名观察者在注射后24小时和48小时进行读数，阳性反应定义为硬结丘疹5毫米或更大。
在注射抗原后24小时和48小时，组织胞浆菌素试验阳性率分别为19.6%和34.0%，反应性显著增加（P = 0.0019）。副球孢子菌素试验在24小时和48小时的阳性率分别为11.3%和19.7%，这种差异也具有显著性（P = 0.004）。无法明确识别出可解释这些反应水平的危险因素。从土壤样本中进行真菌分离的培养和动物接种均为阴性。
副球孢子菌病和组织胞浆菌病在乌帕塔市为地方病。
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