Universidade Federal do Mato Grosso do Sul, Cidade Universitária s/n, Campo Grande, 79070-900, Brazil.
Mycopathologia. 2013 Aug;176(1-2):41-7. doi: 10.1007/s11046-013-9656-x. Epub 2013 Apr 24.
Epidemiological studies of paracoccidioidomycosis have been based on surveys achieved with intradermal tests, and paracoccidioidin is the most common antigen used in most cases. The glycoprotein of 43-kDa (gp43) has been used in intradermal tests. It is the most antigenic component of Paracoccidioides brasiliensis, and it provides greater specificity to evaluate infection for this fungus. In this study, the prevalence of P. brasiliensis infection was estimated with intradermal tests involving gp43 for 695 people in rural Central-West Brazil. The infection rate was 45.8 % (95 % CI = 42.1-49.5), and the average age of those infected was 45.8 ± 18.2 years. The prevalence did not show gender-based differences but increased with age. The results demonstrate the importance of P. brasiliensis infection in rural settlements and the early exposure of children in the region to the fungus. Despite the high antigenicity and specificity of gp43, its usage must be standardized, so that epidemiological surveys will be comparable and more accurately reflect P. brasiliensis infection in endemic areas.
球孢子菌病的流行病学研究一直基于皮内试验调查，而对大多数情况来说，副球孢子菌素是最常用的抗原。43kDa 的糖蛋白（gp43）已被用于皮内试验。它是巴西副球孢子菌最具抗原性的成分，为评估该真菌的感染提供了更高的特异性。在这项研究中，巴西中西部农村地区的 695 人进行了 gp43 皮内试验，以估计巴西副球孢子菌的感染率。感染率为 45.8%（95%CI=42.1-49.5），感染者的平均年龄为 45.8±18.2 岁。感染率没有表现出性别差异，但随着年龄的增长而增加。这些结果表明，巴西副球孢子菌感染在农村地区很重要，而且该地区的儿童很早就接触到了这种真菌。尽管 gp43 具有高抗原性和特异性，但必须对其使用进行标准化，以便流行病学调查具有可比性，并更准确地反映流行地区巴西副球孢子菌的感染情况。
