Mashhood Asher Ahmed, Khan Iqbal Muhammad, Nasir Shagufta, Agha Humayun, Saleem Muhammad, Imran Arshi
Department of Skin, Combined Military Hospital, Peshawar.
J Coll Physicians Surg Pak. 2005 Feb;15(2):71-3.
To compare FNAC with histopathology as an alternate method of diagnosing cutaneous leishmaniasis.
Comparative study.
The duration of the study was from August 2003 to April 2004 at CMH, Peshawar.
A total of 40 patients were included in this study. They were referred from various areas of North-West Frontier Province. FNAC and skin biopsy was performed on every patient. Haematoxylin and eosin (H&E) stain was used for both procedures.
The study group included 39 males and one female, their age ranging from 8-60 years with a mean age of 31.97 years. Detection of LT bodies was considered as a single criterion of the positive result. Histopathological examination was able to diagnose 14 out of 40 patients (positive yield of 35%), while FNAC picked up 11 out of 40 patients (positive yield of 27.5%).
FNAC is easier, less painful and more cost-effective than the conventional skin biopsy. The high sensitivity and specificity eliminate the need for other time-consuming and invasive procedures. However, if LT bodies are not detected then any further comment cannot be made regarding the diagnosis and it is necessary to perform skin biopsy.
比较细针穿刺抽吸活检术（FNAC）与组织病理学检查作为诊断皮肤利什曼病的替代方法。
对比研究。
研究于2003年8月至2004年4月在白沙瓦的CMH进行。
本研究共纳入40例患者。他们来自西北边境省的不同地区。对每位患者均进行了FNAC和皮肤活检。两种检查均使用苏木精和伊红（H&E）染色。
研究组包括39名男性和1名女性，年龄在8至60岁之间，平均年龄为31.97岁。利什曼原虫体的检测被视为阳性结果的单一标准。组织病理学检查能够诊断出40例患者中的14例（阳性率为35%），而FNAC在40例患者中检出11例（阳性率为27.5%）。
FNAC比传统的皮肤活检更容易、痛苦更小且更具成本效益。其高敏感性和特异性消除了对其他耗时且有创检查的需求。然而，如果未检测到利什曼原虫体，则无法对诊断做出进一步评论，此时有必要进行皮肤活检。
