Aydin Omer Faruk, Karakurt Cemşit, Senocak Filiz, Senbil Nesrin, Sungur Metin, Gürer Y K Yavuz
Department of Pediatric Neurology, Dr. Sami Ulus Children's Hospital, 06530 Ankara, Turkey.
Pediatr Neurol. 2005 Mar;32(3):184-9. doi: 10.1016/j.pediatrneurol.2004.09.015.
Autonomic nervous system involvement in subacute sclerosing panencephalitis was studied in 29 patients by analysis of heart rate variability and compared with a control group which consisted of 20 age- and sex-matched healthy subjects. Holter recordings for 24 hours were obtained, and all recordings were analyzed using time-domain parameters. The patients with subacute sclerosing panencephalitis were found to have significantly lower values of standard deviation of all normal sinus intervals and triangular index when compared with the control group. Of 23 patients who had regular follow-up, 15 died in a period ranging from 1 to 13 months. Twelve of these patients had heart rate variability parameters lower than normal, but no significant difference was observed between the heart rate variability values of patients who survived or died. Also, there was no association between brain magnetic resonance imaging findings and heart rate variability indices. It is concluded that patients with subacute sclerosing panencephalitis have autonomic dysfunction; and this was thought to be mainly due to central involvement.
通过分析心率变异性，对29例亚急性硬化性全脑炎患者的自主神经系统受累情况进行了研究，并与由20名年龄和性别匹配的健康受试者组成的对照组进行了比较。获取了24小时的动态心电图记录，并使用时域参数对所有记录进行分析。结果发现，与对照组相比，亚急性硬化性全脑炎患者的所有正常窦性间期标准差和三角指数值显著更低。在23例接受定期随访的患者中，15例在1至13个月的时间段内死亡。这些患者中有12例的心率变异性参数低于正常水平，但存活或死亡患者的心率变异性值之间未观察到显著差异。此外，脑磁共振成像结果与心率变异性指标之间也没有关联。得出的结论是，亚急性硬化性全脑炎患者存在自主神经功能障碍；并且认为这主要是由于中枢受累所致。
