Frye Richard E, Newburger Jane W, Nugent Alan, Sahin Mustafa
Department of Neurology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
Pediatr Neurol. 2005 Mar;32(3):213-6. doi: 10.1016/j.pediatrneurol.2004.07.012.
Although rare, ionic and nonionic contrast-induced seizures occur as a complication of enhanced cranial computed tomography for both adults and children. However, contrast-induced seizures after cardiac catheterization has only been reported in adults. This report describes an 18-month-old male who developed a new-onset focal seizure 12 hours after cardiac catheterization. Unenhanced cranial computed tomography 1 hour after the seizure demonstrated general cerebral edema and unilateral focal cerebral contrast retention with sparing of the area supplied by the middle cerebral artery. The contrast was reabsorbed from the subarachnoid space over a 48-hour period, the cerebral edema resolved over several days, and the child returned to his baseline state 4 days after the seizure episode. This study documents the evolution of computed tomographic findings after contrast-induced seizures in a child. Contrast toxicity should be considered in any case of a new-onset neurologic deficit arising after angiography or enhanced computed tomography.
尽管罕见，但离子型和非离子型造影剂诱发的癫痫发作是成人和儿童增强头颅计算机断层扫描的一种并发症。然而，心脏导管插入术后造影剂诱发的癫痫发作仅在成人中有报道。本报告描述了一名18个月大的男性，在心脏导管插入术后12小时出现新发局灶性癫痫发作。癫痫发作1小时后进行的未增强头颅计算机断层扫描显示广泛性脑水肿和单侧局灶性脑造影剂潴留，大脑中动脉供血区域未受累。造影剂在48小时内从蛛网膜下腔吸收，脑水肿在数天内消退，患儿在癫痫发作后4天恢复到基线状态。本研究记录了儿童造影剂诱发癫痫发作后计算机断层扫描结果的演变。在血管造影或增强计算机断层扫描后出现新发神经功能缺损的任何情况下，都应考虑造影剂毒性。
