氨基-Cope重排反应的应用：四氢吡喃、δ-内酯和哌啶目标产物的合成。
Applications of the amino-Cope rearrangement: synthesis of tetrahydropyran, delta-lactone and piperidine targets.
作者信息
Allin Steven M, Essat Munira, Pita Catarina Horro, Baird Robert D, McKee Vickie, Elsegood Mark, Edgar Mark, Andrews David M, Shah Pritom, Aspinall Ian
机构信息
Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UK LE11 3TU.
出版信息
Org Biomol Chem. 2005 Mar 7;3(5):809-15. doi: 10.1039/b416179c. Epub 2005 Jan 26.
DOI:10.1039/b416179c
PMID:15731867
Abstract
We report a novel approach to some chiral tetrahydropyran and delta-lactone targets that utilizes the asymmetric amino-Cope rearrangement as a key synthetic step. Products of amino-Cope rearrangement chemistry have also been applied to access piperidine targets, further demonstrating the potential of the methodology.
摘要
我们报道了一种用于某些手性四氢吡喃和δ-内酯目标化合物的新方法，该方法将不对称氨基-Cope重排作为关键的合成步骤。氨基-Cope重排化学产物也已应用于制备哌啶目标化合物，进一步证明了该方法的潜力。
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