通过有机催化串联反应对[2,3-b]哌啶内酯骨架进行对映选择性构建。
Enantioselective construction of lactone[2,3-b]piperidine skeletons via organocatalytic tandem reactions.
机构信息
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
出版信息
Org Biomol Chem. 2010 Feb 21;8(4):755-7. doi: 10.1039/b922053d. Epub 2009 Dec 14.
DOI:10.1039/b922053d
PMID:20135029
Abstract
A highly enantioselective construction of delta- and gamma-lactone[2,3-b]piperidine skeletons was accomplished by tandem aza-Diels-Alder reaction-hemiacetal formation-oxidation from N-Tos-1-aza-1,3-butadienes and aliphatic dialdehydes.
摘要
通过 N-Tos-1-氮杂-1,3-丁二烯和脂肪族二醛的串联氮杂 Diels-Alder 反应-半缩醛形成-氧化反应，高对映选择性地构建了 delta-和 gamma-内酯[2,3-b]哌啶骨架。
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