Marraccini P, Previdi M, Costamagna P, Salimbeni Rossana, Todaro A
Dipartimento di Medicina del Lavoro e Sicurezza negli Ambiente di Lavoro, Istituti Clinici di Perfezionamento Milano.
Med Lav. 2004 Nov-Dec;95(6):447-51.
An increased use of acrylic compounds is observed in different industries, home repairs and hobbies. These compounds are known to cause skin sensitisation, irritation of mucous membranes and bronchial asthma. Methyl cyanoacrylate is moderately likely to be a sensitizer, while ethyl cyanoacrylate might be a weak sensitizer.
Clinical evaluation of a case of occupational asthma due to cyanoacrylate.
A female worker, aged 32 years, used ethyl cyanoacrylate daily. After 2 months she experienced dry cough and shortness breath. Some weeks later she developed bronchial asthma. The diagnosis of occupational asthma was based on the work-related symptoms and the inhalation challenge test result.
A late asthmatic response was observed with a maximum fall in FEV1 of 26% 345 minutes after exposure. Complete clinical and functional recovery was observed after inhalation of a broncho-dilating agent.
Acrylates are new occupational sensitising agents, causing rhinitis and asthma. It is not possible to perform prick tests or specific IgE measurements for these compounds. The bronchial challenge test is therefore the sole valid test for the diagnosis of occupational asthma.
在不同行业、家庭维修和业余爱好中，丙烯酸化合物的使用日益增加。已知这些化合物会引起皮肤过敏、黏膜刺激和支气管哮喘。氰基丙烯酸甲酯很可能是一种致敏剂，而氰基丙烯酸乙酯可能是一种弱致敏剂。
对一例因氰基丙烯酸酯导致的职业性哮喘病例进行临床评估。
一名32岁的女性工人每天使用氰基丙烯酸乙酯。2个月后，她出现干咳和呼吸急促。几周后，她患上了支气管哮喘。职业性哮喘的诊断基于与工作相关的症状和吸入激发试验结果。
暴露后345分钟，观察到迟发性哮喘反应，FEV1最大下降26%。吸入支气管扩张剂后，观察到临床和功能完全恢复。
丙烯酸酯是新的职业致敏剂，可引起鼻炎和哮喘。无法对这些化合物进行点刺试验或特异性IgE测量。因此，支气管激发试验是诊断职业性哮喘的唯一有效试验。
