Abramovici M I, Singhal P C, Trachtman H
Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
J Med. 1992;23(1):17-28.
We studied 18 consecutive in-hospital patients with hypernatremia, as well as developed an animal model to simulate hypernatremic dehydration to determine the occurrence of rhabdomyolysis associated with hypernatremia. Mean serum creatine kinase (CPK) levels for the patient group at peak rhabdomyolysis were 3279 +/- 887 IU/L. There was a significant linear correlation between serum sodium and corrected sodium versus CPK (R = 0.585 and 0.713, respectively). In the animal study, mean serum sodium and CPK values were significantly different (p less than 0.0010 and p less than 0.010, respectively). Pre- and post-hypernatremia values of all other electrolytes measured were unchanged. We conclude that hypernatremia has a direct cause and effect relationship with rhabdomyolysis.
我们研究了18例连续住院的高钠血症患者，并建立了一个动物模型来模拟高钠性脱水，以确定与高钠血症相关的横纹肌溶解症的发生情况。横纹肌溶解症高峰期患者组的平均血清肌酸激酶（CPK）水平为3279±887 IU/L。血清钠和校正钠与CPK之间存在显著的线性相关性（分别为R = 0.585和0.713）。在动物研究中，平均血清钠和CPK值有显著差异（分别为p<0.0010和p<0.010）。所测量的所有其他电解质的高钠血症前后值均未改变。我们得出结论，高钠血症与横纹肌溶解症有直接的因果关系。
