植物中同源重组的双重性质。

The dual nature of homologous recombination in plants.

作者信息

Schuermann David, Molinier Jean, Fritsch Olivier, Hohn Barbara

机构信息

Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

出版信息

Trends Genet. 2005 Mar;21(3):172-81. doi: 10.1016/j.tig.2005.01.002.

DOI:10.1016/j.tig.2005.01.002

PMID:15734576

Abstract

Homologous recombination creates covalent linkages between DNA in regions of highly similar or identical sequence. Recent results from several laboratories, many of them based on forward and reverse genetics in Arabidopsis, give insights into the mechanisms of the enzymatic machinery and the involvement of chromatin in somatic and meiotic DNA recombination. Also, signaling pathways and interconnections between repair pathways are being discovered. In addition, recent work shows that biotic and abiotic influences from the environment can dramatically affect plant genomes. The resulting changes in the DNA sequence, exerted at the level of somatic or meiotic tissue, might contribute to evolution.

摘要

同源重组在高度相似或相同序列区域的DNA之间形成共价连接。几个实验室最近的研究结果，其中许多基于拟南芥的正向和反向遗传学，为酶促机制以及染色质在体细胞和减数分裂DNA重组中的作用提供了见解。此外，还发现了信号通路以及修复通路之间的相互联系。另外，最近的研究表明，来自环境的生物和非生物影响会极大地影响植物基因组。在体细胞或减数分裂组织水平上产生的DNA序列变化可能有助于进化。