Kilicaslan Fethi, Verma Atul, Yamaji Hirosuke, Marrouche Nassir F, Wazni Oussama, Cummings Jennifer E, Hao Steven, Andrews Michelle Williams, Beheiry Salwa, Abdul-Karim Ahmad, Belden William A, Minor Stephen, Burkhardt J David, Saliba Walid, Schweikert Robert A, Natale Andrea
Cleveland Clinic Foundation, Section of Pacing and Electrophysiology, Cleveland, Ohio, USA.
J Am Coll Cardiol. 2005 Mar 1;45(5):690-6. doi: 10.1016/j.jacc.2004.11.047.
The aim of this study was to assess the incidence of atrial flutter (AFL) after pulmonary vein antrum isolation (PVAI) in patients with previous cardiac surgery (PCS) in comparison to patients without PCS and to assess the need for AFL ablation in both groups.
Atrial fibrillation (AF) and AFL often co-exist. Pulmonary vein antrum isolation may be sufficient to control both arrhythmias. However, in patients with PCS, atrial incisions, cannulations, and scar areas may cause AFL recurrence despite elimination of pulmonary vein triggers.
Data from 1,345 patients who had PVAI were analyzed. Patients with a history of AFL ablation and patients who had concomitant AFL ablation during PVAI were excluded from analysis. Sixty-three patients constituted the PCS group (Group 1, age 57 +/- 13 years, 12 female) and 1,062 patients constituted the non-PCS group (Group 2, age 55 +/- 12 years, 212 female). Patients in Group 1 had larger left atria, higher incidence of AFL pre-PVAI, and lower ejection fraction.
There was no significant difference in post-PVAI AF recurrence between Groups 1 and 2, but AFL incidence after PVAI was higher in Group 1 (33% vs. 4%, p < 0.0001). Ablation of AFL in Group 1 patients resulted in an 86% acute success rate and 11% recurrence over a mean follow-up of 357 +/- 201 days.
In patients with PCS, post-PVAI AF recurrence is similar to patients without PCS. However, history of PCS is associated with a higher recurrence of AFL after PVAI. In a significant number of patients with PCS, AFL ablation is required to achieve a cure.
本研究旨在评估既往有心脏手术(PCS)的患者与无PCS的患者在肺静脉前庭隔离(PVAI)后房扑(AFL)的发生率,并评估两组患者对AFL消融的需求。
心房颤动(AF)和AFL常并存。肺静脉前庭隔离可能足以控制这两种心律失常。然而,在有PCS的患者中,尽管消除了肺静脉触发因素,但心房切口、插管和瘢痕区域可能导致AFL复发。
分析了1345例行PVAI患者的数据。有AFL消融史的患者和在PVAI期间同时进行AFL消融的患者被排除在分析之外。63例患者构成PCS组(第1组,年龄57±13岁,女性12例),1062例患者构成非PCS组(第2组,年龄55±12岁,女性212例)。第1组患者左心房较大,PVAI前AFL发生率较高,射血分数较低。
第1组和第2组PVAI后AF复发率无显著差异,但第1组PVAI后AFL发生率较高(33%对4%,p<0.0001)。第1组患者AFL消融的急性成功率为86%,平均随访357±201天的复发率为11%。
在有PCS的患者中,PVAI后AF复发与无PCS的患者相似。然而,PCS病史与PVAI后AFL复发率较高相关。在相当数量的有PCS的患者中,需要进行AFL消融以实现治愈。