通过酮合成酶交换得到的新型灵菌红素
New prodiginines from a ketosynthase swap.
作者信息
Parry Ronald J
机构信息
Department of Chemistry, Rice University, Houston, Texas 77005, USA.
出版信息
Chem Biol. 2005 Feb;12(2):145-6. doi: 10.1016/j.chembiol.2005.01.007.
Abstract
The prodiginine antibiotics exhibit antitumor and immunosuppressive activity. In this issue of Chemistry & Biology, Reynolds and coworkers demonstrate that new prodiginines can be obtained by substituting a FabH ketosynthase for the RedP ketosynthase in the undecylprodiginine biosynthetic gene cluster.
摘要
灵菌红素类抗生素具有抗肿瘤和免疫抑制活性。在本期《化学生物学》中，雷诺兹及其同事证明，通过在十一烷基灵菌红素生物合成基因簇中用FabH酮合成酶替代RedP酮合成酶，可以获得新的灵菌红素。
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