轴蛋白与致癌作用之间的联系。
The links between axin and carcinogenesis.
作者信息
Salahshor S, Woodgett J R
机构信息
Ontario Cancer Institute, Division of Experimental Therapeutics, Toronto, Ontario, Canada, M5G 2M9.
出版信息
J Clin Pathol. 2005 Mar;58(3):225-36. doi: 10.1136/jcp.2003.009506.
Abstract
The products of the two mammalian Axin genes (Axin1 and its homologue Axin2) are essential for the degradation of beta catenin, a component of Wnt signalling that is frequently dysregulated in cancer cells. Axin is a multidomain scaffold protein that has many functions in biological signalling pathways. Overexpression of mutant [corrected] axin results in axis duplication in mouse embryos. Wnt signalling activity determines dorsal-ventral axis formation in vertebrates, implicating axin as a negative regulator of this signalling pathway. In addition, Wnts modulate pattern formation and the morphogenesis of most organs by influencing and controlling cell proliferation, motility, and fate. Defects in different components of the Wnt signalling pathway promote tumorigenesis and tumour progression. Recent biochemical studies of axins indicate that these molecules are the primary limiting components of this pathway. This review explores the intriguing connections between defects in axin function and human diseases.
摘要
两种哺乳动物Axin基因（Axin1及其同源物Axin2）的产物对于β-连环蛋白的降解至关重要，β-连环蛋白是Wnt信号通路的一个组成部分，在癌细胞中经常失调。Axin是一种多结构域支架蛋白，在生物信号通路中具有多种功能。突变型[校正后]Axin的过表达导致小鼠胚胎出现轴重复现象。Wnt信号活性决定了脊椎动物背腹轴的形成，这表明Axin是该信号通路的负调节因子。此外，Wnt通过影响和控制细胞增殖、运动和命运来调节大多数器官的模式形成和形态发生。Wnt信号通路不同组分的缺陷会促进肿瘤发生和肿瘤进展。最近对Axin的生化研究表明，这些分子是该通路的主要限制组分。本综述探讨了Axin功能缺陷与人类疾病之间的有趣联系。
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