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测试智能伤口敷料。

Testing intelligent wound dressings.

作者信息

Palamand S, Reed A M, Weimann L J

机构信息

Calgon Vestal Laboratories, St. Louis, MO 63166.

出版信息

J Biomater Appl. 1992 Jan;6(3):198-215. doi: 10.1177/088532829200600302.

Abstract

While occlusive wound dressings help provide patients with moist wound healing to reduce pain and increase reepithelialization rate, the moisture vapor transmission rate (MVTR) of these dressings remains constant even though wound exudate levels may vary with time and from wound to wound. The clinician is therefore faced with exudate buildup in heavily exuding wounds and desiccation in lightly exuding wounds-a situation requiring frequent patient monitoring and dressing changes. Am "intelligent" wound dressing would have the ability to automatically respond to a wound's exudate level by self-adjusting its MVTR to maintain a constant moist wound environment. Such a dressing could help ensure that exudate buildup or wound desiccation is reduced or avoided. Three commercial wound dressings (hydrocolloid, thin film, and membrane laminate) were studied for their ability to alter their MVTR in response to varying moisture level. An efficient test methodology and experimental design was developed, which involved direct and indirect fluid contact with the dressings using two temperatures and two test methods. One dressing, a membrane laminate, was found to exhibit intelligent MVTR behavior. Data is presented which shows this dressing's ability to adjust its MVTR nearly eight-fold as a function of hydration level. Information regarding the mechanism of action of this intelligent dressing is also presented.

摘要

虽然封闭性伤口敷料有助于为患者提供湿性伤口愈合环境,以减轻疼痛并提高上皮再形成率,但即便伤口渗出液水平会随时间以及不同伤口而变化,这些敷料的透湿率(MVTR)却保持恒定。因此,临床医生面临着渗出液较多的伤口出现积液以及渗出液较少的伤口发生干燥的问题——这种情况需要对患者进行频繁监测并更换敷料。一种“智能”伤口敷料应能够通过自我调节其透湿率来自动响应伤口的渗出液水平,从而维持恒定的伤口湿润环境。这样的敷料有助于确保减少或避免渗出液积聚或伤口干燥。研究了三种商用伤口敷料(水胶体、薄膜和膜状层压材料)响应不同湿度水平改变其透湿率的能力。开发了一种有效的测试方法和实验设计,其中包括使用两种温度和两种测试方法使敷料直接和间接接触液体。发现一种膜状层压材料敷料具有智能透湿率行为。给出的数据表明这种敷料能够根据水合作用水平将近八倍地调节其透湿率。还介绍了有关这种智能敷料作用机制的信息。

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