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1
Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis.自我给药增强终纹床核中的兴奋性突触传递。
Nat Neurosci. 2005 Apr;8(4):413-4. doi: 10.1038/nn1414. Epub 2005 Feb 27.
2
A switch in the neuromodulatory effects of dopamine in the oval bed nucleus of the stria terminalis associated with cocaine self-administration in rats.伏隔核终纹床核卵圆形亚核中多巴胺神经调质作用的转换与大鼠可卡因自我给药有关。
J Neurosci. 2011 Jun 15;31(24):8928-35. doi: 10.1523/JNEUROSCI.0377-11.2011.
3
GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats.含GluN2B的N-甲基-D-天冬氨酸受体阻断可挽救可卡因自我给药大鼠终纹床核中的双向突触可塑性。
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4
CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens.腹侧被盖区的 CaMKII 活性控制可卡因诱导的伏隔核突触可塑性。
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5
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.腹侧被盖区中的食欲素A对于可卡因诱导的突触可塑性和行为敏化至关重要。
Neuron. 2006 Feb 16;49(4):589-601. doi: 10.1016/j.neuron.2006.01.016.
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Cocaine self-administration induces changes in synaptic transmission and plasticity in ventral hippocampus.可卡因自我给药会诱导腹侧海马体突触传递和可塑性的变化。
Addict Biol. 2017 Mar;22(2):446-456. doi: 10.1111/adb.12345. Epub 2015 Dec 22.
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Dopamine decreases NMDA currents in the oval bed nucleus of the stria terminalis of cocaine self-administering rats.多巴胺可降低可卡因自我给药大鼠终纹床核椭圆形核中的N-甲基-D-天冬氨酸（NMDA）电流。
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:83-8. doi: 10.1016/j.pnpbp.2014.01.011. Epub 2014 Jan 26.
8
Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis.II 型和 III 型代谢型谷氨酸受体抑制终纹床核背外侧的兴奋性突触传递。
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Temporally dependent changes in cocaine-induced synaptic plasticity in the nucleus accumbens shell are reversed by D1-like dopamine receptor stimulation.在伏隔核壳中，可卡因诱导的突触可塑性的时变依赖性变化可被 D1 样多巴胺受体刺激所逆转。
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10
Prefrontal synaptic markers of cocaine addiction-like behavior in rats.大鼠可卡因成瘾样行为的前额叶突触标志物。
Mol Psychiatry. 2013 Jun;18(6):729-37. doi: 10.1038/mp.2012.59. Epub 2012 May 15.

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Electrophysiologically distinct bed nucleus of the stria terminalis projections to the ventral tegmental area in mice.电生理学上不同的终纹床核投射到小鼠腹侧被盖区。
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Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.伏隔核中的星形胶质细胞N-甲基-D-天冬氨酸受体维持可卡因偏好和神经适应性。
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An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.一个控制可卡因戒断诱导的焦虑和复吸的扩展杏仁核-中脑回路。
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PACAP orchestration of stress-related responses in neural circuits.PACAP 对神经回路中与应激相关反应的协调作用。
Peptides. 2021 Aug;142:170554. doi: 10.1016/j.peptides.2021.170554. Epub 2021 Apr 15.
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NMDA receptors in the CeA and BNST differentially regulate fear conditioning to predictable and unpredictable threats.杏仁中央核和室旁核中的 NMDA 受体对可预测和不可预测威胁的恐惧条件反射有不同的调节作用。
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Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis.乙醇诱导的条件性位置偏爱和厌恶反应差异地改变终纹床核中的可塑性。
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本文引用的文献

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Noradrenaline triggers GABAA inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area.去甲肾上腺素触发γ-氨基丁酸A型受体对投射至腹侧被盖区的终纹床核神经元的抑制作用。
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Evidence for addiction-like behavior in the rat.大鼠成瘾样行为的证据。
Science. 2004 Aug 13;305(5686):1014-7. doi: 10.1126/science.1099020.
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Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning.腹侧纹状体对食欲动机的控制：在摄食行为和奖赏相关学习中的作用。
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Organization of axonal projections from the anterolateral area of the bed nuclei of the stria terminalis.终纹床核前外侧区轴突投射的组织架构
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Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neurons.终纹床核激活腹侧被盖区细胞：一种向中脑多巴胺能神经元输入的新型兴奋性氨基酸通路。
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A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats.杏仁核中央核到终纹床核的含促肾上腺皮质激素释放因子通路在应激诱导大鼠可卡因觅求恢复中的作用。
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Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons.体内单次接触可卡因可诱导多巴胺神经元产生长时程增强效应。
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9
Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats.向终纹床核微量注射阿片受体拮抗剂可抑制成瘾大鼠的海洛因自我给药行为。
Brain Res. 2000 Jan 31;854(1-2):85-92. doi: 10.1016/s0006-8993(99)02288-x.
10
Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion.腹侧前脑的去甲肾上腺素对阿片类药物戒断引起的厌恶至关重要。
Nature. 2000 Jan 27;403(6768):430-4. doi: 10.1038/35000212.

自我给药增强终纹床核中的兴奋性突触传递。

Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis.

作者信息

Dumont Eric C, Mark Gregory P, Mader Sarah, Williams John T

机构信息

The Vollum Institute and Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239, USA.

出版信息

Nat Neurosci. 2005 Apr;8(4):413-4. doi: 10.1038/nn1414. Epub 2005 Feb 27.

DOI:10.1038/nn1414
PMID:15735642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4011824/
Abstract

Understanding the neurobiology of motivation might help in reducing compulsive behaviors such as drug addiction or eating disorders. This study shows that excitatory synaptic transmission was enhanced in the bed nucleus of the stria terminalis of rats that performed an operant task to obtain cocaine or palatable food. There was no effect when cocaine or food was delivered passively, suggesting that synaptic plasticity in this area is involved in reward-seeking behaviors.

摘要

了解动机的神经生物学机制可能有助于减少诸如药物成瘾或饮食失调等强迫行为。这项研究表明，在执行操作性任务以获取可卡因或美味食物的大鼠终纹床核中，兴奋性突触传递增强。当被动给予可卡因或食物时则没有这种效应，这表明该区域的突触可塑性与寻求奖励行为有关。