Ali Tehmina Z, Beyer Ginine, Taylor Michelle, Volpe Carmine, Papadimitriou John C
Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA.
Int J Surg Pathol. 2005 Jan;13(1):103-11. doi: 10.1177/106689690501300116.
Splenic hamartoma (SH) is a rare, benign lesion. We present 2 cases, both in females (2 and 30 years, respectively) with multiple urinary tract infections, and left upper quadrant abdominal pain. Immunohistochemical staining with factor VIII displayed intense diffuse staining in the SH with corresponding weak staining in the adjacent spleen. CD31 showed a reverse pattern from that of factor VIII. CD34 staining pattern was identical in both the spleen and the SH. Ultrastructurally, the SH showed endothelial cells with relatively empty cytoplasm, scattered Weibel Palade bodies, and lining by basement membrane surrounded by fibrous long-spacing collagen. Our study highlights the unique immunohistochemical profile of SH. The ultrastructural features are interesting, although their diagnostic significance remains to be confirmed in future studies.
脾错构瘤（SH）是一种罕见的良性病变。我们报告2例，均为女性（分别为2岁和30岁），有多次尿路感染及左上腹疼痛。用因子VIII进行免疫组织化学染色显示，脾错构瘤中有强烈的弥漫性染色，而相邻脾脏中染色较弱。CD31显示出与因子VIII相反的模式。CD34染色模式在脾脏和脾错构瘤中相同。超微结构上，脾错构瘤显示内皮细胞，其细胞质相对空泡化，有散在的魏-帕小体，由基底膜衬里，基底膜周围有纤维性长间距胶原。我们的研究突出了脾错构瘤独特的免疫组织化学特征。超微结构特征很有趣，尽管其诊断意义有待未来研究证实。
