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[成人脑干胶质瘤及其他肿瘤的外科治疗]

[Surgical treatment of brainstem gliomas and other tumors in adults].

作者信息

Majchrzak Henryk, Krawczyk Lech, Majchrzak Krzysztof, Bierzyńska-Macyszyn Grazyna

机构信息

Katedra i Oddział Kliniczny Neurochirurgii w Sosnowcu, Slaska Akademia Medyczna w Katowicach, ul. Medyków 14, 40-752 Katowice, Poland.

出版信息

Neurol Neurochir Pol. 2005 Jan-Feb;39(1):27-32.

Abstract

BACKGROUND AND PURPOSE

After the introduction of MR imaging to the diagnostics of brainstem tumors and after the introduction of microsurgical procedures to their treatment, the successful treatment, particularly of focal and exophytic forms of these tumors has begun all over the world. The objective of this paper is to establish indications for surgical treatment of gliomas and other tumors of brainstem, to determine surgical approaches and to establish the outcome.

MATERIAL AND METHODS

Within the last 6 years, 12 patients with focal and exophytic tumors of the brainstem in adults were operated on. 5 tumors were located in the midbrain, 4 in the pons, 2 in the medulla oblongata and 1 was a cervicomedullary one. With one exception, all tumors were approached via the posterior fossa.

RESULTS

The total removal was performed in 75% and a subtotal one in 25% of cases. A serious complication in 2 patients was bilateral ptosis after the removal of midbrain tumors. This lesion gradually regressed. A similar dangerous complication is impaired swallowing and coughing reflex loss which, by exposing the patient to the risk of aspiration pneumonia, occurred in 2 patients. One of these patients died after the operation.

CONCLUSIONS

Patients with focal and exophytic forms of the brainstem tumors in MR imaging are qualified for surgical treatment. Immediate results of the treatment depend on the localization and size of the neoplasm. A precise operative approach, use of the neurophysiological examination and postoperative care at the Intensive Care Unit are essential conditions to obtain good results of the operative treatment.

摘要

背景与目的

自从磁共振成像被应用于脑干肿瘤的诊断以及显微外科手术被应用于其治疗后,全世界范围内针对这些肿瘤,尤其是局灶性和外生性肿瘤的成功治疗已经开始。本文的目的是确定脑干胶质瘤和其他肿瘤的手术治疗适应证,确定手术入路并评估治疗结果。

材料与方法

在过去6年中,对12例患有成人脑干局灶性和外生性肿瘤的患者进行了手术。5例肿瘤位于中脑,4例位于脑桥,2例位于延髓,1例为颈髓延髓交界区肿瘤。除1例例外,所有肿瘤均经后颅窝入路。

结果

75%的病例实现了肿瘤全切,25%的病例为次全切。2例患者在切除中脑肿瘤后出现严重并发症,表现为双侧上睑下垂,该病变逐渐消退。另外2例患者出现了类似的危险并发症,即吞咽障碍和咳嗽反射消失,这使患者面临吸入性肺炎的风险,其中1例患者术后死亡。

结论

磁共振成像显示为局灶性和外生性的脑干肿瘤患者适合接受手术治疗。治疗的近期效果取决于肿瘤的位置和大小。精确的手术入路、神经生理学检查的应用以及重症监护病房的术后护理是获得良好手术治疗效果的必要条件。

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