Muster Tim H, Prestidge Clive A
Ian Wark Research Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
J Pharm Sci. 2005 Apr;94(4):861-72. doi: 10.1002/jps.20296.
Water sorption kinetics and water contact angles have been characterized for a range of pharmaceutical powders: ambroxol hydrochloride, griseofulvin, N,n-octyl-D-gluconamide, paracetamol, sulfathiazole, and theophylline. The uptake of water by powder samples at saturated vapor pressure was modeled using a pseudo first-order kinetic relationship. Parameters from this model have been correlated with the concentration and reactivity of the active surface sites of the pharmaceutical powders and their contact angles. The study has shown that analysis of water adsorption kinetics can be a powerful technique for characterizing the surface chemistry and wettability of pharmaceutical powders, and is particularly sensitive to their surface modification through excipient adsorption: ethyl(hydroxyethyl)cellulose treatment of griseofulvin and butyryl chloride treatment of sulfathiazole are reported as case studies.
盐酸氨溴索、灰黄霉素、N,N-辛基-D-葡糖酰胺、对乙酰氨基酚、磺胺噻唑和茶碱。使用伪一级动力学关系对粉末样品在饱和蒸气压下的吸水情况进行了建模。该模型的参数已与药用粉末活性表面位点的浓度和反应性及其接触角相关联。研究表明，水吸附动力学分析可以成为表征药用粉末表面化学性质和润湿性的有力技术，并且对通过辅料吸附进行的表面改性特别敏感：作为案例研究报道了用乙基（羟乙基）纤维素处理灰黄霉素和用丁酰氯处理磺胺噻唑。
