Czarnobaj K, Lukasiak J
Department of Physical Chemistry with Laboratory of Instrumental Analysis, Medical University of Gdańsk, al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Drug Deliv. 2004 Nov-Dec;11(6):341-4. doi: 10.1080/10717540490507451.
Cisplatin an antineoplastic medicine, was incorporated into a silica gel received by the sol-gel method. Various techniques of trapping an active substance in gel were applied: at the stage of sol creation--by the predoping method--and already upon receipt of hard xerogel--the postdoping method. Further, the research aimed at the determination of the dynamics of cisplatin release from sol-gel processed silica xerogel to the water phase. Based on the achieved results, we may state that the sol-gel method is useful for trapping a medicine like cisplatin in silica gel and gives repeatable results with regard to medicine release from the pores of the so-established matrix. The postdoping method appeared to be more beneficial, because the gained gel's active substance is released almost entirely (94-96%). The time of release was 3 days.
顺铂是一种抗肿瘤药物，通过溶胶-凝胶法被掺入硅胶中。采用了多种将活性物质捕获在凝胶中的技术：在溶胶形成阶段——通过预掺杂法——以及在获得硬质干凝胶后——采用后掺杂法。此外，该研究旨在确定顺铂从溶胶-凝胶处理的二氧化硅干凝胶释放到水相中的动力学。基于所取得的结果，我们可以说溶胶-凝胶法对于将顺铂这样的药物捕获在硅胶中是有用的，并且在所建立的基质孔隙中药物释放方面能给出可重复的结果。后掺杂法似乎更有利，因为所获得凝胶中的活性物质几乎完全释放（94 - 96%）。释放时间为3天。
