Czarnobaj Katarzyna, Lukasiak Jerzy
Department of Physical Chemistry with Laboratory of Instrumental Analysis, Medical University of Gdansk, al. Gen. J. Hallera 107, Gdansk 80-416, Poland.
J Mater Sci Mater Med. 2007 Oct;18(10):2041-4. doi: 10.1007/s10856-007-3139-x. Epub 2007 Jun 9.
SiO2, SiO2/PEG and SiO2/PDMS xerogels were examined as polymeric carriers for the controlled release of cisplatin--an antineoplasmic medicine. Drug/carrier systems were prepared by the sol-gel method. The effect of organic substitution of the silica xerogel matrix and drying conditions on the release of cisplatin was evaluated. Based on the presented results of the study it may be stated that sol-gel method is useful for entrapping a cisplatin in the pores of organically modified silica gels and for releasing cisplatin mainly in the way of diffusion from the pores of the lattice under the in vitro conditions. The use of organic impurities in silica gel increased the release of cisplatin from xerogel (from 62% to 97% within 7 days), and thermal treatment of all xerogels with cisplatin at the temperature of 80 degrees C resulted in the acceleration of the drug release (2 days) and increase of the released drug (89-98%).
二氧化硅（SiO₂）、二氧化硅/聚乙二醇（SiO₂/PEG）和二氧化硅/聚二甲基硅氧烷（SiO₂/PDMS）干凝胶作为顺铂（一种抗肿瘤药物）控释的聚合物载体进行了研究。药物/载体系统通过溶胶-凝胶法制备。评估了二氧化硅干凝胶基质的有机取代和干燥条件对顺铂释放的影响。根据本研究给出的结果，可以说溶胶-凝胶法可用于将顺铂包封在有机改性硅胶的孔隙中，并且在体外条件下，顺铂主要以从晶格孔隙扩散的方式释放。硅胶中使用有机杂质增加了顺铂从干凝胶中的释放（7天内从62%增加到97%），并且在80℃温度下对所有含顺铂的干凝胶进行热处理导致药物释放加速（2天）和释放药物增加（89%-98%）。
