Kostamo K, Richardson M, Malmberg H, Ylikoski J, Ranta H, Toskala E
Department of Otorhinolaryngology, Helsinki University Hospital, Haartmaninkatu, Helsinki, Finland.
Indoor Air. 2005 Apr;15(2):112-9. doi: 10.1111/j.1600-0668.2004.00322.x.
Here we evaluated a possible relationship between chronic hyperplastic sinusitis (CHS) and moisture exposure and secondly a seasonal variation of fungal and bacterial findings in the healthy nose. In 28 CHS patients sinus mucus was collected during endoscopic sinus surgery. Samples from the nasal cavities of 19 healthy volunteers were collected by nasal lavage (NAL) in January and in September. Bacterial culture and fungal staining and culture were carried out. Histological samples from the sinus mucosa were obtained. Patients' medical history and environmental factors were enquired. Mold odor or moisture problems in the home or work environment were reported by 46% of the CHS patients. Patients who reported moisture exposure did not differ significantly from those who had not been exposed with regards to microbiological findings, tissue eosinophilia, and earlier operations. Cladosporium (16%) and Alternaria (11%) were found in NAL fluid collected in the autumn from the control subjects. No fungi were isolated from samples taken during the winter. An association between CHS or fungal sinusitis and moisture damage was not apparent in the present study. The fungal findings in the nasal cavity reflect the environmental exposure. This should be taken into account when NAL is used for microbiological studies.
Living in a moldy house or working in a similar environment may increase the risk of respiratory symptoms and infections. However, our results suggest that chronic hyperplastic sinusitis and fungal sinusitis are not associated with moisture exposure. The nose is a good collector of particles in the air. Especially samples taken by the nasal lavage method reflect the environmental exposure. This should be taken into account when this method is used for microbiological studies.
在此，我们评估了慢性增生性鼻窦炎（CHS）与接触湿气之间可能存在的关系，其次评估了健康鼻腔中真菌和细菌检测结果的季节性变化。在28例CHS患者接受鼻内镜手术期间收集鼻窦黏液。19名健康志愿者的鼻腔样本于1月和9月通过鼻腔灌洗（NAL）采集。进行细菌培养、真菌染色和培养。获取鼻窦黏膜的组织学样本。询问患者的病史和环境因素。46%的CHS患者报告家中或工作环境存在霉菌气味或湿气问题。报告有湿气接触的患者在微生物学检测结果、组织嗜酸性粒细胞增多以及早期手术方面与未接触湿气的患者相比无显著差异。从秋季对照组受试者收集的NAL液中发现了枝孢菌（16%）和链格孢菌（11%）。冬季采集的样本未分离出真菌。在本研究中，CHS或真菌性鼻窦炎与湿气损害之间的关联不明显。鼻腔中的真菌检测结果反映了环境暴露情况。在将NAL用于微生物学研究时应考虑到这一点。
生活在发霉的房屋中或在类似环境中工作可能会增加呼吸道症状和感染的风险。然而，我们的结果表明慢性增生性鼻窦炎和真菌性鼻窦炎与接触湿气无关。鼻腔是空气中颗粒的良好收集器。特别是通过鼻腔灌洗法采集的样本反映了环境暴露情况。在将该方法用于微生物学研究时应考虑到这一点。
