影响绵羊源杀菌肽对大肠杆菌O157:H7抗菌活性的因素。
Factors affecting the antimicrobial activity of ovine-derived cathelicidins against E. coli 0157:H7.
作者信息
Anderson Rachel C, Yu Pak-Lam
机构信息
Biotechnology Group, Institute of Technology and Engineering, Massey University, Private Bag 11-222, Palmerston North, New Zealand.
出版信息
Int J Antimicrob Agents. 2005 Mar;25(3):205-10. doi: 10.1016/j.ijantimicag.2004.10.010. Epub 2005 Jan 20.
Antimicrobial peptides extracted from ovine neutrophils have potential to be high-value by-products of the lamb industry as, for example, a biopreservative for chilled lamb products. This work was carried out to determine the conditions in which ovine peptides are most effective and to assist in product development. The activities of three synthetic ovine-derived antimicrobial peptides tested were not significantly affected by pH or temperature. However, they exhibited decreased activity at high ionic strengths and in the presence of divalent cations. The three peptides worked better in combination than individually.
从绵羊嗜中性粒细胞中提取的抗菌肽有潜力成为羊肉产业的高价值副产品，例如，可作为冷藏羊肉产品的生物防腐剂。开展这项工作是为了确定绵羊抗菌肽最有效的条件，并助力产品开发。所测试的三种合成绵羊源抗菌肽的活性不受pH值或温度的显著影响。然而，在高离子强度和二价阳离子存在的情况下，它们的活性会降低。这三种肽组合使用时比单独使用效果更好。
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