Doyle D V, Dunn C J, Willoughby D A
J Pathol. 1979 Jun;128(2):63-9. doi: 10.1002/path.1711280203.
Hydroxyapatite crystal deposition is thought to play a role in the inflammatory episodes of osteoarthritis. A plaque of hydroxyapatite crystals was produced by local subcutaneous injection of a potassium permanganate solution. Transmission electron microscopy with X-ray energy spectroscopy was used to identify the crystal deposits as hydroxyapatite. The effects of dexamethasone, indomethacin, ethane 1-hydroxy-1, 1-diphosphonate (EHDP) and dichloromethylene diposphonate (Cl2MDP) on the development of the apatite plaque was studied. EHDP strongly inhibited the apatite deposition. Cl2MDP slowed the natural resorption of the apatite plaque. Dexamethasone and indomethacin failed to affect the crystal deposition process. The results suggest that EHDP could inhibit crystal deposition in the osteoarthritic joint and that Cl2MDP might have a role in slowing apatite crystal shedding from osteoarthritic cartilage and so reduce the synovitis seen in Osteoarthritis.
羟基磷灰石晶体沉积被认为在骨关节炎的炎症发作中起作用。通过局部皮下注射高锰酸钾溶液产生了一块羟基磷灰石晶体。使用透射电子显微镜结合X射线能谱来鉴定晶体沉积物为羟基磷灰石。研究了地塞米松、吲哚美辛、乙烷1-羟基-1,1-二膦酸盐（EHDP）和二氯亚甲基二膦酸盐（Cl2MDP）对磷灰石斑块形成的影响。EHDP强烈抑制磷灰石沉积。Cl2MDP减缓了磷灰石斑块的自然吸收。地塞米松和吲哚美辛未能影响晶体沉积过程。结果表明，EHDP可以抑制骨关节炎关节中的晶体沉积，并且Cl2MDP可能在减缓磷灰石晶体从骨关节炎软骨中脱落方面起作用，从而减轻骨关节炎中出现的滑膜炎。
