Moreno Ruben G M, Alipázaga Maria V, Medeiros Marisa H G, Coichev Nina
Instituto de Quimica, Universidade de Sao Paulo, CP 26077, CEP 05513-970, Sao Paulo, SP-Brazil.
Dalton Trans. 2005 Mar 21(6):1101-7. doi: 10.1039/b416299d. Epub 2005 Feb 21.
Copper(II)/(III) tetraglycine complexes were investigated for their ability to catalyze the autoxidation of sulfite resulting in oxidative DNA damage. The focus of this work is on DNA damage by Cu(III) and oxysulfur radicals formed by the oxidation of S(IV) oxides by dissolved oxygen in the presence of Cu(II) tetraglycine complexes. The results suggest that sulfite is rapidly oxidized by oxygen in the presence of Cu(II) complexes producing Cu(III) tetraglycine, which can be monitored spectrophotometrically at 365 nm. A synergistic effect of Cu(II) with a second metal ion (Ni(II), Co(II) or Mn(II) traces) was observed.
研究了铜（II）/（III）四甘氨酸配合物催化亚硫酸盐自氧化导致氧化DNA损伤的能力。这项工作的重点是研究在铜（II）四甘氨酸配合物存在下，铜（III）和由溶解氧氧化S（IV）氧化物形成的氧硫自由基对DNA的损伤。结果表明，在铜（II）配合物存在下，亚硫酸盐会被氧气迅速氧化生成铜（III）四甘氨酸，可通过分光光度法在365nm处进行监测。观察到铜（II）与第二种金属离子（痕量镍（II）、钴（II）或锰（II））具有协同效应。
