Meaume S, Colin D, Barrois B, Bohbot S, Allaert F A
Geriatric Department, Hôpital Charles Foix, Ivry sur Seine, France.
J Wound Care. 2005 Feb;14(2):78-82. doi: 10.12968/jowc.2005.14.2.26741.
To determine which factors contribute to the development of pressure ulcers and to evaluate the role of topical agents in preventing their occurrence.
An observational, prospective survey covered 36 care of the elderly wards and involved 1121 patients at high or very high risk of pressure ulceration. The patients, of whom 667 (59.6%) received a gentle application of a topical agent to at-risk areas, were followed up for eight weeks.
Of the patients, 15.7% developed a pressure ulcer. The use of a corpitolinol 60-based topical agent (Sanyrène/Corpitol) significantly reduced the incidence of pelvic pressure ulcers (p=0.04) when used with recognised prevention strategies. This was identified by undertaking a logistic regression analysis. The resulting odds ratio of 0.61 indicates that the intervention helped to reduce the number of pressure ulcers by 40%.
The results of this observational study can provide a useful guide to the design of further randomised controlled trials.
确定哪些因素会导致压疮的发生，并评估局部用药在预防压疮发生中的作用。
一项观察性前瞻性调查涵盖了36个老年护理病房，涉及1121名发生压疮高风险或极高风险的患者。对其中667名（59.6%）在高危部位轻柔涂抹局部用药的患者进行了为期八周的随访。
在这些患者中，15.7%发生了压疮。与公认的预防策略联合使用时，使用含60%考匹托醇的局部用药（Sanyrène/Corpitol）可显著降低盆腔压疮的发生率（p=0.04）。这是通过逻辑回归分析得出的。得出的优势比为0.61，表明该干预措施有助于将压疮数量减少40%。
这项观察性研究的结果可为进一步的随机对照试验设计提供有用的指导。
