Lee Seung Woong, Lee Hyun Sun, Nam Jung Yeon, Kwon Oh Eok, Baek Jin Ah, Chang Jong Sun, Rho Mun-Chual, Kim Young Kook
Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, 52 Eoun-dong, Taejeon 305-333, Republic of Korea.
J Ethnopharmacol. 2005 Mar 21;97(3):515-9. doi: 10.1016/j.jep.2004.12.006.
The accumulation of circulating monocytes in the arterial wall is an early in atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) promotes the migration of monocytes and would play a role in the development of atherosclerotic lesions. Searching for inhibitors of MCP-1-induced cell migration from natural sources, we isolated one active compound through active-guided fractionations from the MeOH extracts of Sophora flavescens Ait (Leguminosae). On the basis of spectral evidence, the structure of active compound was identified as kurarinone. It inhibited the migration of THP-1 cells induced by MCP-1 with IC50 value of 19.2 microg/mL. In addition, it inhibited the binding of MCP-1 to THP-1 cells and phosphorylation of p42/44 MARK.
