Nakamura Mariko, Ogawa Tomoo, Yokono Akira, Nakamori Shogo, Ohno Tsuneya, Umezawa Kazuo
Department of Microbiology, The Jikei University School of Medicine 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461 Japan.
Biomed Pharmacother. 2005 Jan-Feb;59(1-2):47-50. doi: 10.1016/j.biopha.2004.05.017. Epub 2005 Jan 26.
The combined effect against human immunodeficiency virus (HIV) of oxanosine and 2'3'-dideoxyinosine (ddI) has been evaluated by the production of viral particles, the expression of viral antigens on cell surfaces, and the amount of viral genome integrated in the host cells. Oxanosine alone has no effect on HIV replication up to 100 microg/ml, however, in the presence of ddI, oxanosine revealed concentration dependent inhibition against HIV without cytotoxicity.
已通过病毒颗粒的产生、细胞表面病毒抗原的表达以及整合到宿主细胞中的病毒基因组数量，评估了氧杂核苷与2',3'-双脱氧肌苷（ddI）联合抗人类免疫缺陷病毒（HIV）的效果。单独使用氧杂核苷时，在浓度高达100微克/毫升时对HIV复制无影响，然而，在存在ddI的情况下，氧杂核苷显示出对HIV的浓度依赖性抑制作用且无细胞毒性。
