氯氮平：一对同卵双胞胎中与精神分裂症和轻度智力障碍一致的体重增加情况。
Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation.
作者信息
Wehmeier Peter M, Gebhardt Stefan, Schmidtke Jörg, Remschmidt Helmut, Hebebrand Johannes, Theisen Frank M
机构信息
Department of Child and Adolescent Psychiatry, Philipps-University, Hans-Sachs-Str. 4-8, 35033 Marburg, Germany.
出版信息
Psychiatry Res. 2005 Feb 28;133(2-3):273-6. doi: 10.1016/j.psychres.2004.02.018.
Clozapine is an atypical antipsychotic known to cause considerable weight gain. The extent to which genetic factors determine weight gain is unknown. Here we report on a pair of female monozygotic twins concordant for schizophrenia and mild mental retardation who were treated with clozapine over 5.5 years. One twin gained a total of 53.1 kg and had a weight of 107.5 kg (BMI=38.1 kg/m2) at the end of the observation period. The other twin gained a total of 48.2 kg and finally had a weight of 100.4 kg (BMI=33.8 kg/m2). Because both patients experienced considerable weight gain during treatment, our observation suggests that the antipsychotic-induced weight gain is under strong genetic control.
氯氮平是一种非典型抗精神病药物，已知会导致显著体重增加。遗传因素在多大程度上决定体重增加尚不清楚。在此，我们报告一对同卵双胞胎女性，她们患有精神分裂症和轻度智力障碍，接受氯氮平治疗超过5.5年。其中一个双胞胎共增重53.1千克，在观察期结束时体重为107.5千克（体重指数=38.1千克/平方米）。另一个双胞胎共增重48.2千克，最终体重为100.4千克（体重指数=33.8千克/平方米）。由于两名患者在治疗期间均出现显著体重增加，我们的观察表明抗精神病药物引起的体重增加受强大的遗传控制。
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