Singh Th David, Sumitra Ch, Yaiphaba N, Devi H Debecca, Devi M Indira, Singh N Rajmuhon
Department of Chemistry, Nagaland University-Lumami, Mokokchung 798601, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2005 Apr;61(6):1219-25. doi: 10.1016/j.saa.2004.06.044.
The coordination chemistry of glutathione reduced (GSH) is of great importance as it acts as excellent model system for the binding of metal ions. The GSH complexation with metal ions is involved in the toxicology of different metal ions. Its coordination behaviour for soft metal ions and hard metal ions is found different because of the structure of GSH and its different potential binding sites. In our work we have studied two chemically dissimilar metal ions viz. Pr(III), which prefer hard donor site like carboxylic groups and Zn(II) the soft metal ion which prefer peptide-NH and sulphydryl groups. The absorption difference and comparative absorption spectroscopy involving 4f-4f transitions of the heterobimetallic Complexation of GSH with Pr(III) and Zn(II) has been explored in aqueous and aquated organic solvents. The variation in the energy parameters like Slater-Condon (F(K)), Racah (E(K)) and Lande (xi(4f)), Nephelauxetic parameter (beta) and bonding parameter (b(1/2)) are computed to explain the nature of complexation.
还原型谷胱甘肽（GSH）的配位化学非常重要，因为它是金属离子结合的优秀模型系统。GSH与金属离子的络合作用涉及不同金属离子的毒理学。由于GSH的结构及其不同的潜在结合位点，发现它与软金属离子和硬金属离子的配位行为不同。在我们的工作中，我们研究了两种化学性质不同的金属离子，即Pr(III)，它更喜欢像羧基这样的硬供体位点，以及Zn(II)，软金属离子更喜欢肽-NH和巯基。在水性和水合有机溶剂中，探索了涉及GSH与Pr(III)和Zn(II)异双金属络合的4f-4f跃迁的吸收差异和比较吸收光谱。计算了能量参数如Slater-Condon（F(K)）、Racah（E(K)）和Lande（ξ(4f)）、电子云扩展参数（β）和键合参数（b(1/2)）的变化，以解释络合的性质。
