用于唾液酸模拟物平行合成的定制醛缩酶的构建。 - Suppr

Suppr

超能文献

Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics.

作者信息

Woodhall Thomas, Williams Gavin, Berry Alan, Nelson Adam

机构信息

School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.

出版信息

Angew Chem Int Ed Engl. 2005 Mar 29;44(14):2109-12. doi: 10.1002/anie.200462733.

DOI:10.1002/anie.200462733

PMID:15742315

Abstract

摘要

相似文献

Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics.

Angew Chem Int Ed Engl. 2005 Mar 29;44(14):2109-12. doi: 10.1002/anie.200462733.

Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics.

Protein Eng Des Sel. 2005 May;18(5):239-46. doi: 10.1093/protein/gzi027. Epub 2005 May 16.

Directed evolution of D-sialic acid aldolase to L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolase.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9122-6. doi: 10.1073/pnas.0504033102. Epub 2005 Jun 20.

Synthesis and evaluation of C-9 modified N-acetylneuraminic acid derivatives as substrates for N-acetylneuraminic acid aldolase.

Bioorg Med Chem. 2000 Mar;8(3):657-64. doi: 10.1016/s0968-0896(99)00325-9.

Preparation of a fluorous protecting group and its application to the chemoenzymatic synthesis of sialidase inhibitor.

Chem Commun (Camb). 2006 Aug 7(29):3093-4. doi: 10.1039/b605519b. Epub 2006 Jun 13.

Enzymatic generation and in situ screening of a dynamic combinatorial library of sialic acid analogues.

Angew Chem Int Ed Engl. 2002 Sep 16;41(18):3405-7. doi: 10.1002/1521-3773(20020916)41:18<3405::AID-ANIE3405>3.0.CO;2-P.

Cloning, expression, and characterization of sialic acid synthases.

Biochem Biophys Res Commun. 2005 Dec 23;338(3):1507-14. doi: 10.1016/j.bbrc.2005.10.113. Epub 2005 Oct 27.

Efficient synthesis of 4-amido-N(5)-acetyl-4-deoxyneuraminic acid and its application to the C-4 modification of sialic acids.

Org Lett. 2009 Aug 20;11(16):3678-81. doi: 10.1021/ol901511x.

Biological chemistry: enzymes in focus.

Nature. 2005 Aug 25;436(7054):1096-7. doi: 10.1038/4361096a.

Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics.

J Org Chem. 2010 May 7;75(9):2861-76. doi: 10.1021/jo100017t.

引用本文的文献

Catalytic Asymmetric Transfer Hydrogenation of β,γ-Unsaturated α-Diketones.

J Am Chem Soc. 2024 Dec 11;146(49):33543-33560. doi: 10.1021/jacs.4c11070. Epub 2024 Nov 27.

Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition-Transamination Reactions.

ACS Catal. 2021 Apr 16;11(8):4660-4669. doi: 10.1021/acscatal.1c00210. Epub 2021 Apr 2.

A 96-multiplex capillary electrophoresis screening platform for product based evolution of P450 BM3.

Sci Rep. 2019 Oct 29;9(1):15479. doi: 10.1038/s41598-019-52077-w.

Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity.

Org Biomol Chem. 2016 Jan 7;14(1):105-12. doi: 10.1039/c5ob02037a. Epub 2015 Nov 5.

Computational tools for rational protein engineering of aldolases.

Comput Struct Biotechnol J. 2012 Nov 13;2:e201209016. doi: 10.5936/csbj.201209016. eCollection 2012.

Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis.

Future Med Chem. 2011 May;3(7):809-19. doi: 10.4155/fmc.11.48.

Structural insights into substrate specificity in variants of N-acetylneuraminic Acid lyase produced by directed evolution.

J Mol Biol. 2010 Nov 19;404(1):56-69. doi: 10.1016/j.jmb.2010.08.008. Epub 2010 Sep 6.

Protein promiscuity and its implications for biotechnology.

Nat Biotechnol. 2009 Feb;27(2):157-67. doi: 10.1038/nbt1519.

Directed evolution of aldolases for exploitation in synthetic organic chemistry.

Arch Biochem Biophys. 2008 Jun 15;474(2):318-30. doi: 10.1016/j.abb.2008.01.005. Epub 2008 Jan 19.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验