Holm-Pedersen Poul, Avlund Kirsten, Morse Douglas E, Stoltze Kaj, Katz Ralph V, Viitanen Matti, Winblad Bengt
Copenhagen Gerontological Oral Health Research Center, University of Copenhagen, School of Dentistry, Copenhagen, Denmark.
J Am Geriatr Soc. 2005 Mar;53(3):430-7. doi: 10.1111/j.1532-5415.2005.53160.x.
To examine whether caries or periodontitis is associated with cardiac arrhythmias in community-dwelling people aged 80 and older.
Urban, community-based population in Stockholm, Sweden.
Cross-sectional.
Eligible persons were identified through the Kungsholmen Project, which is an ongoing, longitudinal, population-based study of the oldest old. The present study included 125 dentate individuals.
Data from interviews, a medical examination, and an oral examination. The assessment of cardiac arrhythmia was based on a clinical examination by a physician or the Stockholm Inpatient Register. Active root caries, active coronal caries, and periodontitis were assessed using previously defined National Institute of Dental and Craniofacial Research diagnostic criteria.
The primary finding of the multivariate logistic regression analysis was that persons with three or more active root caries lesions had more than twice the odds of cardiac arrhythmias than persons without active root caries. The results did not notably change after adjusting for age, medications that reduce saliva, and number of teeth. Persons with one to two active coronal caries lesions had 2.8 times higher odds (95% confidence interval=1.1-7.0) of arrhythmia than persons without active coronal caries, but there was no greater risk for persons with three or more coronal caries lesions. There was no association between periodontal disease and arrhythmia.
The findings indicate that there may be a link between active root caries and cardiac arrhythmias in the oldest old. Nevertheless, although a biological pathway is not obvious, it is plausible that both are simply markers of declining general health. The results suggest the need for further study of these relationships.
研究80岁及以上社区居住人群中龋齿或牙周炎是否与心律失常有关。
瑞典斯德哥尔摩的城市社区人群。
横断面研究。
符合条件的个体通过Kungsholmen项目确定，该项目是一项正在进行的、基于人群的、针对高龄老人的纵向研究。本研究纳入了125名有牙个体。
来自访谈、医学检查和口腔检查的数据。心律失常的评估基于医生的临床检查或斯德哥尔摩住院登记。使用先前定义的美国国立牙科和颅面研究所诊断标准评估活动性根龋、活动性冠龋和牙周炎。
多因素逻辑回归分析的主要发现是，有三个或更多活动性根龋病变的人患心律失常的几率是没有活动性根龋的人的两倍多。在调整年龄、减少唾液分泌的药物和牙齿数量后，结果没有明显变化。有一到两个活动性冠龋病变的人患心律失常的几率比没有活动性冠龋的人高2.8倍（95%置信区间=1.1-7.0），但有三个或更多冠龋病变的人没有更大的风险。牙周疾病与心律失常之间没有关联。
研究结果表明，高龄老人中活动性根龋与心律失常之间可能存在联系。然而，尽管生物学途径不明显，但两者都可能只是总体健康状况下降的标志，这是有道理的。结果表明需要进一步研究这些关系。
