Mizuno Soichi, Mihara Takumi, Miyaoka Tsuyoshi, Inagaki Takuzi, Horiguchi Jun
Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
J Sleep Res. 2005 Mar;14(1):43-7. doi: 10.1111/j.1365-2869.2004.00403.x.
The aim of this study is evaluating iron, ferritin, and transferrin in both serum and CSF in patients of restless legs syndrome (RLS), based on the hypothesis that iron deficiency in the central nervous system (CNS) causes the symptoms as a result of the dysfunction of dopaminergic systems. These parameters, polysomnographic sleep measures, and subjective evaluation of the sleep quality were compared in 10 patients of idiopathic RLS (RLS group) and 10 age-matched patients of psychophysiological insomnia without RLS symptoms (non-RLS group). With sleep patterns, sleep latency was longer and sleep efficiency was lower in the RLS group than those in the non-RLS group. Periodic leg movement index in the RLS group was higher than that of the non-RLS group. With serum examination, there were no significant differences for the iron, ferritin, and transferrin values between the both groups. With CSF examination, the iron and ferritin values were lower and the transferrin values were higher in the RLS group than those in the non-RLS group. There was positive correlation between the serum and CSF ferritin levels in the both groups, but the slope of the regression lines for the RLS group was lower than that for the non-RLS group. These results indicate low brain iron concentration caused by the dysfunction of iron transportation from serum to CNS in patients with idiopathic RLS.
本研究的目的是评估不宁腿综合征（RLS）患者血清和脑脊液中的铁、铁蛋白及转铁蛋白，基于以下假设：中枢神经系统（CNS）缺铁由于多巴胺能系统功能障碍而导致症状出现。对10例特发性RLS患者（RLS组）和10例年龄匹配的无RLS症状的心理生理性失眠患者（非RLS组）的这些参数、多导睡眠图睡眠指标及睡眠质量主观评估进行了比较。在睡眠模式方面，RLS组的睡眠潜伏期长于非RLS组，睡眠效率低于非RLS组。RLS组的周期性腿部运动指数高于非RLS组。血清检查显示，两组之间的铁、铁蛋白及转铁蛋白值无显著差异。脑脊液检查显示，RLS组的铁和铁蛋白值低于非RLS组，转铁蛋白值高于非RLS组。两组血清和脑脊液铁蛋白水平之间均呈正相关，但RLS组回归线的斜率低于非RLS组。这些结果表明，特发性RLS患者血清至CNS的铁转运功能障碍导致脑铁浓度降低。
