Wetter T C, Stiasny K, Kohnen R, Oertel W H, Trenkwalder C
Max Planck Institute of Psychiatry, Munich, Germany.
Mov Disord. 1998 Sep;13(5):820-4. doi: 10.1002/mds.870130511.
In the present study, the nocturnal electroencephalographic sleep pattern, the number of periodic leg movements (PLM) during sleep and wakefulness, and the subjective sleep parameters of patients with uremic (n = 10) and idiopathic (n = 17) restless legs syndrome (RLS) were compared. The main finding was that the total number of PLM (p = 0.019), the PLM index (p = 0.018), and the PLM index while awake (p = 0.003) were significantly higher in patients with uremic RLS compared with patients who had idiopathic RLS. Additionally, both groups showed a distinct time-of-night pattern of PLM activity. Polysomnographic measures of sleep continuity (total sleep time, sleep efficiency, sleep onset latency, time awake) and sleep architecture (amount of nonrapid eye movement sleep stages 1, 2, 3, and 4 and the amount of rapid eye movement sleep) did not differ between uremic and idiopathic RLS patients. With regard to subjective parameters, sleep quality was estimated to be worse in uremic RLS (p = 0.033), whereas other parameters (for example, severity of RLS, quality of life) did not differ between the two groups. It is suggested that uremia itself worsens the motor symptoms of RLS, probably as a result of increased excitability.
在本研究中，对尿毒症性（n = 10）和特发性（n = 17）不宁腿综合征（RLS）患者的夜间脑电图睡眠模式、睡眠和清醒期间的周期性腿部运动（PLM）次数以及主观睡眠参数进行了比较。主要发现是，与特发性RLS患者相比，尿毒症性RLS患者的PLM总数（p = 0.019）、PLM指数（p = 0.018）以及清醒时的PLM指数（p = 0.003）显著更高。此外，两组均显示出PLM活动明显的夜间时间模式。尿毒症性和特发性RLS患者在睡眠连续性（总睡眠时间、睡眠效率、入睡潜伏期、清醒时间）和睡眠结构（非快速眼动睡眠1、2、3和4期的量以及快速眼动睡眠的量）的多导睡眠图测量方面没有差异。关于主观参数，尿毒症性RLS患者的睡眠质量估计更差（p = 0.033），而其他参数（例如，RLS的严重程度、生活质量）在两组之间没有差异。提示尿毒症本身会加重RLS的运动症状，可能是由于兴奋性增加所致。
