香姜的成分及其对CYP3A4和CYP2D6的抑制活性。

Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity.

作者信息

Usia Tepy, Kadota Shigetoshi, Tezuka Yasuhiro

机构信息

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2005 Mar;53(3):333-5. doi: 10.1248/cpb.53.333.

DOI:10.1248/cpb.53.333

PMID:15744110

Abstract

A new sesquiterpene 2,9-humuladien-6-ol-8-one (1) was isolated from methanol extract of Zingiber aromaticum, along with 15 known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibitory activity on the metabolism mediated by cytochrome P450 3A4 (CYP3A4) and CYP2D6.

摘要

从香姜的甲醇提取物中分离出一种新的倍半萜2,9-葎草二烯-6-醇-8-酮（1），以及15种已知化合物。通过光谱分析确定了分离出的化合物的结构。测试了分离出的化合物对细胞色素P450 3A4（CYP3A4）和CYP2D6介导的代谢的抑制活性。