Igisu H, Mawatari S, Kuroiwa Y
Neurology. 1979 Jul;29(7):992-5. doi: 10.1212/wnl.29.7.992.
The ATP and lactate contents of erythrocytes from patients with Duchenne muscular dystrophy (DMD) were measured before and after incubation with or without glucose plus either ouabain or propranolol. Samples from patients and controls were obtained at almost the same time on the same day and processed simultaneously. The erythrocyte ATP content differed in adults and children, but there was no difference between DMD patients and age-matched controls. Ouabain suppressed, and propranolol enhanced, the changes of ATP and lactate, to the same extent in patients and in controls. We found no gross abnormalities in generation and utilization of ATP in erythrocytes in DMD, and the response to ouabain or propranolol appeared normal.
在有或没有葡萄糖以及哇巴因或普萘洛尔存在的情况下孵育前后，对杜氏肌营养不良症（DMD）患者的红细胞中的ATP和乳酸含量进行了测量。患者和对照组的样本在同一天几乎同一时间获取并同时进行处理。红细胞ATP含量在成人和儿童中有所不同，但DMD患者与年龄匹配的对照组之间没有差异。哇巴因抑制了ATP和乳酸的变化，而普萘洛尔增强了这种变化，在患者和对照组中程度相同。我们发现DMD患者红细胞中ATP的生成和利用没有明显异常，并且对哇巴因或普萘洛尔的反应似乎正常。
