人胚胎口面部区域中p53、p63和p73的表达

Expression of p53, p63 and p73 in the orofacial region of human embryos.

作者信息

Cernochová Drahomíra, Pospísilová Eva, Kylarová Dana

机构信息

Department of Histology and Embryology, Faculty of Medicine, Palacký University, Olomouc, Czech Republic.

出版信息

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2004 Dec;148(2):203-4.

PMID:15744376

Abstract

We studied p53, p63, p73 protein expression in the orofacial region of five human embryos aged 7-18 weeks of intrauterine development using a three-step immunohistochemical method. Expression of proteins in various locations was evaluated semiquantitatively. A decrease in p53, p63 and p73 proteins occurred in the 13-week-old material with the exception of the tooth germ where a drop in p73 appeared in the ninth week.

摘要

我们使用三步免疫组织化学方法研究了5个宫内发育7至18周的人类胚胎口面部区域中p53、p63、p73蛋白的表达情况。对不同部位蛋白质的表达进行了半定量评估。在13周龄的样本中，p53、p63和p73蛋白表达下降，但牙胚除外，在牙胚中p73蛋白在第9周时出现下降。