Cernochová Drahomíra, Pospísilová Eva, Kylarová Dana
Department of Histology and Embryology, Faculty of Medicine, Palacký University, Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2004 Dec;148(2):203-4.
We studied p53, p63, p73 protein expression in the orofacial region of five human embryos aged 7-18 weeks of intrauterine development using a three-step immunohistochemical method. Expression of proteins in various locations was evaluated semiquantitatively. A decrease in p53, p63 and p73 proteins occurred in the 13-week-old material with the exception of the tooth germ where a drop in p73 appeared in the ninth week.
我们使用三步免疫组织化学方法研究了5个宫内发育7至18周的人类胚胎口面部区域中p53、p63、p73蛋白的表达情况。对不同部位蛋白质的表达进行了半定量评估。在13周龄的样本中，p53、p63和p73蛋白表达下降，但牙胚除外，在牙胚中p73蛋白在第9周时出现下降。
