Min Ji-Won, Lee June-Hyuk, Park Choon-Sik, Chang Hun Soo, Rhim Tai Youn, Park Sung-Woo, Jang An-Soo, Shin Hyoung-Doo
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 1174, Jung Dong, Wonmi Ku, Bucheon, Gyeonggi Do, 420-021, Korea.
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Chongro 4 Ga, Chongro-Gu, Seoul, Korea, 110-834.
J Hum Genet. 2005;50(3):118-123. doi: 10.1007/s10038-005-0230-3. Epub 2005 Mar 3.
Chemokine (C-C motif) ligand 24 (CCL24, eotaxin-2) is a CC chemokine that recruits and activates cells bearing the CC chemokine receptor 3, which play a major role in asthma. Previously, we observed a significant association between a single nucleotide polymorphism (SNP) in eotaxin-2 (CCL24+1272A--> G) and a lower risk of asthma. Consequently, this study has followed up on those genetic effects by evaluating the association between the SNP and plasma eotaxin-2 concentration in 172 asthmatics and 135 normal controls. Asthmatics had significantly higher plasma eotaxin-2 levels than did normal controls (P=0.02). The SNP (CCL24+1272A--> G) and two haplotypes (ht2 and ht6) were strongly associated with plasma eotaxin-2 levels in asthmatics (CCL24+1272A--> G: P=0.006, ht2: P=0.006, and ht6: P=0.002). The CCL24+1272A--> G allele and the ht2 and ht6 haplotypes showed a gene-dose effect on the plasma eotaxin-2 levels in asthmatics (P=0.005-0.032). In conclusion, the susceptibility of patients with asthma to high eotaxin-2 production may be due to genetic effects of the CCL24+1272A--> G polymorphism, ht2 and ht6 haplotypes.
趋化因子（C-C基序）配体24（CCL24，嗜酸性粒细胞趋化因子-2）是一种CC趋化因子，可募集并激活携带CC趋化因子受体3的细胞，该受体在哮喘中起主要作用。此前，我们观察到嗜酸性粒细胞趋化因子-2中的单核苷酸多态性（SNP）（CCL24 +1272A→G）与较低的哮喘风险之间存在显著关联。因此，本研究通过评估172例哮喘患者和135例正常对照中该SNP与血浆嗜酸性粒细胞趋化因子-2浓度之间的关联，对这些遗传效应进行了随访。哮喘患者的血浆嗜酸性粒细胞趋化因子-2水平显著高于正常对照（P = 0.02）。SNP（CCL24 +1272A→G）和两种单倍型（ht2和ht6）与哮喘患者的血浆嗜酸性粒细胞趋化因子-2水平密切相关（CCL24 +1272A→G：P = 0.006，ht2：P = 0.006，ht6：P = 0.002）。CCL24 +1272A→G等位基因以及ht2和ht6单倍型对哮喘患者的血浆嗜酸性粒细胞趋化因子-2水平显示出基因剂量效应（P = 0.005 - 0.032）。总之，哮喘患者对高嗜酸性粒细胞趋化因子-2产生的易感性可能归因于CCL24 +1272A→G多态性、ht2和ht6单倍型的遗传效应。
