Gartenmaier A, Pelzer E, Soyka M
Pharmacopsychiatry. 2005 Mar;38(2):96-8. doi: 10.1055/s-2005-837810.
The most frequently used agents for treatment of alcohol withdrawal syndrome are benzodiazepines and clomethiazole. Both have the main disadvantage of potential misuse and respiratory depression. Therefore their use in patients with respiratory diseases is limited. In recent years a treatment strategy with combined carbamazepine and tiapride was reported to be an effective alternative in alcohol withdrawal without the risk of respiratory depression. We report the successful treatment with carbamazepine and tiapride of a patient with probable sleep apnoe syndrome and history of withdrawal-related epileptic seizures.
治疗酒精戒断综合征最常用的药物是苯二氮卓类和氯美噻唑。两者都有潜在滥用和呼吸抑制的主要缺点。因此,它们在患有呼吸系统疾病的患者中的应用受到限制。近年来,有报道称卡马西平和硫必利联合治疗策略是酒精戒断的一种有效替代方法,且无呼吸抑制风险。我们报告了一例可能患有睡眠呼吸暂停综合征且有戒断相关癫痫发作史的患者,使用卡马西平和硫必利成功治疗的病例。