Ghi P, Blengio M, Ferretti C, Portaleone P
Institute of Pharmacology and Pharmacognosy, School of Pharmacy, University of Torino, Italy.
Pharmacol Biochem Behav. 1992 Feb;41(2):317-20. doi: 10.1016/0091-3057(92)90104-n.
A weak electric foot-shock stressful stimulus (0.5 mA x 1 s x 5 times) significantly increases plasma corticosterone (CS) levels and modifies [3H]-histamine ([3H]-HA) binding site constants related to H2 receptors in rat cortical membranes. Progressive and total recovery of basal binding characteristics occurs 90 min later. A double-foot-shock stress procedure delays [3H]-HA binding characteristic recovery instead of strengthening stress effects. This finding is further evidence of involvement of the brain's histamine receptors in the response to mild stress.
轻度电足部电击应激刺激（0.5毫安×1秒×5次）显著提高大鼠血浆皮质酮（CS）水平，并改变大鼠皮质膜中与H2受体相关的[3H]-组胺（[3H]-HA）结合位点常数。90分钟后，基础结合特性逐渐并完全恢复。双足部电击应激程序延迟了[3H]-HA结合特性的恢复，而非增强应激效应。这一发现进一步证明了脑组胺受体参与了对轻度应激的反应。
