Ghi P, Ferretti C, Blengio M, Portaleone P
Institute of Pharmacology and Pharmacognosy, School of Pharmacy, University of Torino, Italy.
Pharmacol Biochem Behav. 1995 May;51(1):65-8. doi: 10.1016/0091-3057(94)00359-q.
The involvement of the histaminergic system in the regulation of weak stress was studied in rats. The parameters examined were the brain receptors and corticosterone (CS) plasma levels. The benzodiazepine diazepam [(2 mg/kg intraperitoneally (IP)] influenced neither foot-shock-induced changes in CS levels nor [3H]-histamine [(3H)-HA] binding site constants, whereas the tricyclic antidepressive amitriptyline (10 mg/kg IP) partially counteracted a plasma CS increase and prevented changes in [3H]-HA binding in the stressed rat brain. These observations are in agreement with the known activities of amitriptyline on monoaminergic metabolism and receptors. Moreover, these data provide further experimental evidence of the functional role of the central histaminergic system in organized stress response.
在大鼠中研究了组胺能系统在弱应激调节中的作用。所检测的参数为脑受体和血浆皮质酮（CS）水平。苯二氮䓬类药物地西泮[腹腔注射（IP）2mg/kg]既不影响足部电击诱导的CS水平变化，也不影响[³H] - 组胺[（³H）-HA]结合位点常数，而三环类抗抑郁药阿米替林（IP 10mg/kg）部分抵消了血浆CS的升高，并阻止了应激大鼠脑中[³H] - HA结合的变化。这些观察结果与阿米替林对单胺能代谢和受体的已知作用一致。此外，这些数据为中枢组胺能系统在有组织的应激反应中的功能作用提供了进一步的实验证据。
