Hogardt M, Heesemann J
Max von Pettenkofer-Institut der LMU, München.
MMW Fortschr Med. 2005 Jan 27;147(4):38-40.
The pathogenesis of lung infections in patients with mucoviscidosis (cystic fibrosis, CF) is multifactorial. Both host- and pathogen-related factors are involved. The most important germ in terms of progression and pulmonary damage is Pseudomonas aeruginosa. However, the clinical relevance of other CF-typical pathogens has not yet been determined with certainty, and must be assessed on the basis of the clinical presentation of the individual case. To ensure optimal patient management, a CF-specific microbiological diagnostic work-up is mandatory. Since ever more patients now survive into adulthood, the problems associated with chronic infection are gaining in importance. In light of increasing multiresistance, the use of inhalation antibiotics, as well as combined antibiotic treatment, is becoming more and more determinative for the therapeutic outcome.
黏液黏稠症（囊性纤维化，CF）患者肺部感染的发病机制是多因素的。宿主相关因素和病原体相关因素均有涉及。就病情进展和肺部损伤而言，最重要的病原体是铜绿假单胞菌。然而，其他CF典型病原体的临床相关性尚未明确确定，必须根据个别病例的临床表现进行评估。为确保对患者进行最佳管理，必须进行CF特异性微生物学诊断检查。由于现在越来越多的患者存活至成年，与慢性感染相关的问题日益重要。鉴于多重耐药性不断增加，吸入性抗生素的使用以及联合抗生素治疗对治疗结果越来越具有决定性作用。
