在多个家族中未证实HLA与精神分裂症之间的关系。

Relationship of HLA to schizophrenia not supported in multiplex families.

作者信息

Campion D, Leboyer M, Hillaire D, Halle L, Gorwood P, Cavelier B, Soufflet M F, d'Amato T, Muller B, Kaplan C

机构信息

Unité de Recherche d'Epidemiologie Genetique (I.N.S.E.R.M. U 155), Château de Longchamp, Paris, France.

出版信息

Psychiatry Res. 1992 Feb;41(2):99-105. doi: 10.1016/0165-1781(92)90102-9.

DOI:10.1016/0165-1781(92)90102-9

PMID:1574545

Abstract

The role of the human histocompatibility complex (HLA) in the pathogenesis of schizophrenia has been suggested in previous reports. We conducted a genetic study in 33 new families. Our linkage analysis, which used the affected sib-pair method, did not provide evidence for nonrandom assortment. Moreover, the results of an association study using the "haplotype relative risk" method failed to confirm the positive association between HLA A9 and schizophrenia. Taken together, our data did not support any relationship of HLA type to schizophrenia.

摘要

先前的报告已表明人类组织相容性复合体（HLA）在精神分裂症发病机制中的作用。我们对33个新家庭进行了一项遗传学研究。我们采用受累同胞对法进行的连锁分析未提供非随机分配的证据。此外，使用“单倍型相对风险”方法进行的关联研究结果未能证实HLA A9与精神分裂症之间的正相关。综合来看，我们的数据不支持HLA类型与精神分裂症之间存在任何关联。