强效且具选择性的[2-咪唑-1-基-2-(6-烷氧基萘-2-基)-1-甲基-乙基]-二甲基胺类作为维甲酸代谢阻断剂（RAMBAs）。
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
作者信息
Mulvihill Mark J, Kan Julie L C, Beck Patricia, Bittner Mark, Cesario Cara, Cooke Andrew, Keane David M, Nigro Anthony I, Nillson Christy, Smith Vanessa, Srebernak Mary, Sun Feng-Lei, Vrkljan Michael, Winski Shannon L, Castelhano Arlindo L, Emerson David, Gibson Neil
机构信息
OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA.
出版信息
Bioorg Med Chem Lett. 2005 Mar 15;15(6):1669-73. doi: 10.1016/j.bmcl.2005.01.044.
PMID:15745819
Abstract
A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's).
摘要
设计并合成了一系列[2-咪唑-1-基-2-(6-烷氧基萘-2-基)-1-甲基乙基]-二甲胺作为细胞色素P450 26（CYP26）抑制剂，用作维甲酸代谢阻断剂（RAMBA）。
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