LIAZAL的合成，一种视黄酸代谢阻断剂（RAMBA），在肿瘤学和皮肤病学领域具有潜在临床应用价值。
Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.
作者信息
Freyne E, Raeymaekers A, Venet M, Sanz G, Wouters W, De Coster R, Wauwe J V
机构信息
Department of Medicinal Chemistry, Janssen Research Foundation, Beerse, Belgium.
出版信息
Bioorg Med Chem Lett. 1998 Feb 3;8(3):267-72. doi: 10.1016/s0960-894x(98)00004-3.
PMID:9871667
Abstract
The synthesis of LIAZAL (compound 9, R085246) is described. LIAZAL inhibits all-trans-retinoic acid metabolism and thereby exerts retinoid-like effects in vivo.
摘要
描述了LIAZAL（化合物9，R085246）的合成。LIAZAL抑制全反式维甲酸代谢，从而在体内发挥类视黄醇样作用。
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