Lohse Brian, Ramanujam P S, Hvilsted Søren, Berg Rolf H
Danish Polymer Centre, Risø National Laboratory, Roskilde.
J Pept Sci. 2005 Jul;11(8):499-505. doi: 10.1002/psc.645.
Ten N(epsilon)-glycylornithineamide derivatives have been synthesized containing various N(alpha)-linked pyrimidine-1-ylacetyl groups which can undergo (2pi + 2pi) photodimerization on irradiation with UV light at 254 nm. The dimerization efficiency of the free and bound pyrimidine groups was compared in aqueous solution: it was dependent on the substitution of the pyrimidine ring. N(alpha),N(alpha')-bis-(uracil-1-ylacetyl)-(N(epsilon)-glycylornithineamide) and N(alpha),N(alpha')-bis-(5-bromouracil-1-ylacetyl)-(N(epsilon)-glycylornithineamide) were identified as possible candidates for optical data storage.
已经合成了十种含有各种N(α)-连接的嘧啶-1-基乙酰基的N(ε)-甘氨酰鸟氨酸酰胺衍生物，这些衍生物在254nm紫外光照射下可发生(2π + 2π)光二聚反应。在水溶液中比较了游离和结合嘧啶基团的二聚化效率：它取决于嘧啶环的取代情况。N(α),N(α')-双-(尿嘧啶-1-基乙酰基)-(N(ε)-甘氨酰鸟氨酸酰胺)和N(α),N(α')-双-(5-溴尿嘧啶-1-基乙酰基)-(N(ε)-甘氨酰鸟氨酸酰胺)被确定为光学数据存储的可能候选物。
